Search results for "Pain generation"

showing 3 items of 3 documents

Evidence of neurotrophic events due to peritoneal endometriotic lesions

2012

To investigate the neurotrophic properties of endometriosis, as well as the involvement of neurotrophic factors in the development of chronic pelvic pain in patients with endometriosis, we performed a prospective clinical study. The presence of neurotrophins was investigated in the peritoneal fluid (PF) of patients with peritoneal endometriotic lesions or adenomyosis, as well as from women with non-endometriotic adhesions and from women without endometriosis/adenomyosis/adhesions. The PF from patients with peritoneal endometriotic lesions was divided in three groups: asymptomatic endometriosis, minimal pain and severe pain. PF from patients with adenomyosis or with non-endometriotic adhesio…

AdultPathologymedicine.medical_specialtyImmunologyEndometriosisEndometriosisTissue AdhesionsBiochemistryCell LineYoung AdultPelvic painNeurotrophin 3Neurotrophic propertieNeurotrophic factorsGanglia SpinalmedicineNeuritesAnimalsAscitic FluidHumansImmunology and AllergyAdenomyosisProspective StudiesEndometriosiMolecular BiologyBrain-derived neurotrophic factorbiologybusiness.industryPeritoneal fluidPelvic painBrain-Derived Neurotrophic FactorMedicine (all)HematologyMiddle Agedmedicine.diseaseNerve growth factorPain generationbiology.proteinFemaleNeurotrophinmedicine.symptomChronic PainPeritoneumbusinessChickensAdenomyosisNeurotrophin
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Imbalance between sympathetic and sensory innervation in peritoneal endometriosis

2011

To investigate possible mechanisms of pain pathophysiology in patients with peritoneal endometriosis, a clinical study on sensory and sympathetic nerve fibre sprouting in endometriosis was performed. Peritoneal lesions (n= 40) and healthy peritoneum (n= 12) were immunostained and analysed with anti-protein gene product 9.5 (PGP 9.5), anti-substance P (SP) and anti-tyrosine hydroxylase (TH), specific markers for intact nerve fibres, sensory nerve fibres and sympathetic nerve fibres, respectively, to identify the ratio of sympathetic and sensory nerve fibres. In addition, immune cell infiltrates in peritoneal endometriotic lesions were analysed and the nerve growth factor (NGF) and interleuki…

Sensory and sympathetic innervationPathologySympathetic nervous systemSympathetic Nervous SystemInterleukin-1betaEndometriosisSubstance PSubstance PSensory Receptor CellBehavioral Neurosciencechemistry.chemical_compoundNerve FibersGAP-43 ProteinGanglia SpinalNerve Growth FactorAscitic FluidMedicineEndometriosis; Neurotransmitters; Sensory and sympathetic innervationEndometriosiNGFImmunity CellularGanglia SympatheticNeurotransmittersMiddle AgedImmunohistochemistrymedicine.anatomical_structureNerve FiberIL-1βPain generation of endometriosis-related symptomFemaleUbiquitin ThiolesteraseHumanSensory nerveAdultmedicine.medical_specialtySensory Receptor CellsTyrosine 3-MonooxygenaseNeuriteImmunologyEndometriosisYoung AdultImmune cell infiltratePeritoneumInternal medicineHumansNerve Growth FactorsNeurotransmitterCell ProliferationInflammationEndocrine and Autonomic Systemsbusiness.industryStromal Cellmedicine.diseaseSensory Receptor CellsNerve growth factorEndocrinologychemistryLaparoscopyStromal CellsbusinessChronic pelvic painBrain, Behavior, and Immunity
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Influence of nerve growth factor in endometriosis-associated symptoms

2011

To investigate the role of the nerve growth factor (NGF) in the development of dysmenorrhea/pelvic pain in patients with endometriosis, we performed a prospective, clinical, blind study. Peritoneal fluids (PFs) were obtained from patients with histologically proven endometriosis. Patients with endometriosis were divided into 7 different groups depending on their preoperative pain score and symptomatology: patients with no pain, patients with minimal pain (dysmenorrhea, pelvic pain, or both), and patients with severe pain (dysmenorrhea, pelvic pain, or both) and were used for the neuronal growth assay with cultured chicken dorsal root ganglia (DRG) and for Western blot analyses. Dorsal root …

endometriosisEndometriosisFluorescent Antibody TechniqueChick EmbryoGastroenterologypain generation of endometriosis-related symptomSeverity of Illness Indexendometriosis; pelvic pain; sensory nerve fibersGAP-43 ProteinGanglia SpinalGermanyNerve Growth FactorAscitic FluidProspective StudiesEndometriosiProspective cohort studyCells CulturedPain MeasurementNeuronsbiologymedicine.diagnostic_testObstetrics and Gynecologypelvic painMiddle AgedBlotAnesthesiaFemalemedicine.symptomNeurotrophinHumanAdultmedicine.medical_specialtyCalcitonin Gene-Related PeptideBlotting Westernsensory nerve fibersCalcitonin gene-related peptidesensory nerve fiberYoung AdultWestern blotDysmenorrheaInternal medicinemedicineAnimalsHumansbusiness.industryAnimalPelvic painNeuronmedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaProspective StudieNerve growth factorbiology.proteinbusiness
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